At the forefront of life, technology, and many areas of research, computational methods are consistently increasing in applicability and power. A key focus of my research is linking together different scales and disciplines in science. My bachelor's work used density functional theory to study fundamental reactions in organic synthesis (Seitz et al, JOC 2016). This chemistry background formed the basis of my PhD work, where my applications shifted to basic biology and global diseases. I used elastic network models to study plant respiration (Takahashi et al, Sci. Adv. 2022) and prokaryotic "proto-nuclei" (Laughlin and Deep et al, Nature 2022). I also extensively studied molecular recognition in influenza through Brownian dynamics (Seitz et al, Biophys. J. 2020), molecular dynamics and Markov state models (Casalino et al, ACS Cent. Sci. 2022). Finally, I went back to my density functional theory roots for a measles drug discovery project (Ahn and Seitz et al, DIB 2021). Bringing forward my newfound skills in biophysics along with my chemistry training, my postdoc work is on artificial intelligence in viruses and vaccine development.
Publications
Bryn N. K. Lopez, Paulo H. O. Ceciliato, Yohei Takahashi, Felipe J. Rangel, Evana A. Salem, Klara Kernig, Kelly Chow, Li Zhang, Morgana A. Sidhom, Christian G. Seitz, Tingwen Zheng, Richard Sibout, Debbie L. Laudencia-Chingcuanco, Daniel P. Woods, James Andrew McCammon, John P. Vogel, Julian I. Schroeder
Plant Physiology, vol. 196(1), 2024, pp. 495-510
Targeting Tuberculosis: Novel Scaffolds for Inhibiting Cytochrome bd Oxidase.
Christian Seitz, Surl-Hee Ahn, Haixin Wei, Matson Kyte, Gregory M. Cook, Kurt L. Krause, J. Andrew McCammon
Journal of Chemical Information and Modeling, vol. 64(13), 2024, pp. 5232-5241
John H. Kim, Aashish Shivkumar, Masaki Norimoto, Sascha Castro Lingl, Christian Seitz, Rommie. E. Amaro, Steve L. Gonias, Jerry Yang, Wendy M. Campana
Biochemistry, vol. 63(6), 2024, pp. 725-732
Glycosylation and Crowded Membrane Effects on Influenza Neuraminidase Stability and Dynamics
Christian Seitz, İlker Deveci, J. Andrew McCammon
The Journal of Physical Chemistry Letters, vol. 14, 2023, pp. 9926-9934
Breathing and Tilting: Mesoscale Simulations Illuminate Influenza Glycoprotein Vulnerabilities
Lorenzo Casalino, Christian Seitz, Julia Lederhofer, Yaroslav Tsybovsky, Ian A. Wilson, Masaru Kanekiyo, Rommie E. Amaro
ACS Central Science, vol. 8(12), 2022, pp. 1646-1663
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Courses
TA, UCSD
Numerical Analysis in Multiscale Biology
Laboratory course teaching computational biology techniques
General chemistry laboratory
TA for an introductory chemistry laboratory Winner of the Fall 2016 TA award from UCSD
Posts
Grad school application advice
I’ve finally been prompted enough to share some knowledge I’ve learned about applying to grad schools. This has been my experience applying to chemistry schools mostly in the US, and may not be representative for other disciplines or countries. Some of...
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NSF GRFP application advice
I've finally decided to create a professional website, and will be putting these things on there to make it easier to share with others. My out-of-order tips would be: - Start early (preferably 2-3 months before the deadline) - Set your goal to make...
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